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Kohl's smartly even admits it needs an expanded data set to draw any larger scale conclusions.
By analysing such a significantly expanded data set, phylogenomics is likely to result in reduced statistical errors and to reveal true evolutionary relationships more reliably.
Investigators were prompted to provide an expanded data set on the electronic case report form for days 1, 2, 3, 5, 7, 10, 14, 21, and 28 or at ICU discharge or death.
These questions are similar as asked in the paper by Holtmann et al. (2010), but we ask these questions of a significantly expanded data set and in the context of diagnostic categories such as SMD and DMDD being discussed in the literature as part of a broader 'paediatric bipolar phenotype'.
With an expanded data set, we have been able to compare the strength of these relationships and their degree of phylogenetic dependence.
Using our expanded data set, we performed both maximum likelihood (ML) and Bayesian phylogenetic analyses.
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Hence, expanded data sets of gene relationships in the Bacteria could be used to further resolve the phylogeny of these weak RP divisions (Figure 3).
Further studies will be required to determine whether enterotypes are consistently found in expanded data sets and in studies of intestinal biopsies as well as the fecal samples used in the MetaHit study.
Exploitation of the expanding data set has largely been limited to co-expression analysis of genes and comparisons between experimental factors (growth conditions, treatments, specific mutations, etc).
Of course, subtler and more nuanced 80/20 KPIs can be winkled out from expanding data sets.
Here, we review the recent progress that resulted specifically from exome sequencing and emphasize the need for rigorous statistical evaluation of the expanding data sets, as well as expanded functional analysis of implicated proteins and mutations.
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