Exact(18)
In order to avoid excessive host tissue injury whilst protecting effectively against infectious agents, the immune system features regulatory mechanisms to control the production and response to cytokines.
Immune responsive cells have evolved negative regulatory mechanisms that function at multiple levels to effectively terminate an immune response and to prevent excessive host damage.
Influenza-related mortality has been variously ascribed to an ineffective host response that fails to limit viral replication, an excessive host inflammatory response that results in lung injury and impairment of gas exchange, or to bacterial superinfection.
Our results suggest, however, a possible therapeutic approach in which A. fumigatus infection is treated by a combination of antifungals and MAPK inhibitors which can modulate an excessive host inflammatory response [37], [53].
Deregulated or excessive host immune responses contribute to the pathogenesis of sepsis.
Herein, we investigated whether PD-1 prevents excessive host tissue damage during infection with the protozoan parasite, Toxoplasma gondii.
Similar(42)
The latter-day king of awards-show hosts — remember his tour-de-force Tony opener in June? — was somehow reduced to eating his own tail, appearing in a lame sketch about Excessive Hosting Disorder and performing a mindless halftime song-and-dance number called "The Number in the Middle of the Show".
This is implicated as an adaptive measure to prevent excessive inflammatory host tissue damage.
The complement system orchestrates the immunologic network and links to elements of both innate and adaptive immunity and is an important inducer of an excessive inflammatory host response and contributes to the clinical course, prognosis, and complications of sepsis [ 2, 3].
While that might seem excessive, co-host Tameron Hall pointed out that passengers already pay to board early.
Epichloe festuca-synthesized ROS regulate hyphal tip growth, thereby restricting growth of the fungus and preventing excessive colonization and host defense gene activation [ 31, 32].
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