All 1,538 DNA samples used in this study were obtained from 30 ethnic panels of immortalized cell lines created by the Chinese Human Genome Diversity Project (CHGDP) [27], [28].
RHH is convenient to execute (e.g. in not requiring phased chromosomes or allele frequencies from ethnic panels) and RHH numerical and visual output is also easily understood by the non-specialist since it is transparent (i.e. counts and chromosomal locations of rare genotypes whose highest dataset frequencies are user-specified).
With respect to inter-population diversity, our multi-ethnic panel showed levels of population differentiation similar to those previously observed [50], with a significant global FST (merging all samples) averaged over the 20 genomic regions equal to 0.12.
Imputation was performed using MACH and minimac software (http://www.sph.umich.edu/csg/abecasis/mach/) based on phase 1 alpha freeze version 3 data of the 1000 Genomes Project multi-ethnic panel.
Sequencing of the coding exons in a multi-ethnic panel of 95 women with advanced breast cancer provided 85% power to identify putative functional coding variants with frequencies as low as 1% in the combined sample.
Analyses of the sequence of the whole gene in a multi-ethnic panel of individuals have shown that DC-SIGN has been under strong selective constraints, preventing the accumulation of aminoacid changes over time.
Ethnicity was ascribed on the basis of a multi-ethnic panel of researchers using all available information including self acription, place of birth, and parental place of birth, the final decision being that of the researcher.
Genet., submitted) has examined 69 risk regions among a multi-ethnic sample panel comprising European (8600 cases and 6946 controls), African (5327 cases and 5136 controls), Asian (2563 cases and 4391 controls) and Latino (1034 cases and 1046 controls) ethnicities.
Motivation: To increase the signal resolution for large-scale meta-analyses of genome-wide association studies, genotypes at unmeasured single nucleotide polymorphisms (SNPs) are commonly imputed using large multi-ethnic reference panels.
Figure 2 summarizes the quantitative results in micrograms of lipid and the comparative analysis of the sebaceous lipid classes among the three different ethnic groups, total (top panel), 18‒25 y (middle panel) and 35‒45 y (bottom panel).
The htSNPs provide a minimum RH of 0.77 to describe the haplotype diversity among Japanese, Whites, and Latinas from the Multi-Ethnic Cohort selection panel [ 49].
