Sentence examples similar to Establish modifications in from inspiring English sources

It will be important to determine the functional and temporal relationships among these established modifications in modulating the accumulation of PHF-tau in AD and other age-related neurodegenerative diseases.

In this case, eRNAs could be by-products of RNA polymerase II elongation for establishing active histone modifications in enhancers.

It is well established that specific modifications in sodium reabsorption in proximal tubule cells lead to an increase in renal sodium and water excretion as observed in primary hypertension [ 20- 23].

Since the m1A58 modification on tRNALys is consistently absent in MERRF myoblasts and skeletal muscle, we asked whether re-establishing the modification in the MERRF myoblasts could modulate mitochondrial translation.

Although carboxylation of glutamate residues is an established posttranslational modification in conotoxins, it should be noted that this carboxylase is highly conserved in a wide variety of organisms, including humans and Drosophila.

So far dozens of genes are known to encode proteins that establish or remove histone modifications in the human genome.

These findings illustrate how genome organization and sequence might establish and maintain epigenetic modifications in complex genomes and thereby directly impact biological function(s).

Compounds that promote chromatin remodeling have been of particular interest because of the critical roles of DNA and histone modifications in establishing and maintaining differentiated cell fates.

Therefore, it is suggested that CYC-like TCP genes have been recruited multiple times for a role of dorsal identity and its modifications in establishing zygomorphy in core eudicots [ 3, 19].

However, phenotypic characterization of these mice and embryo fibroblasts derived from them, has established the role of these modifications in the regulation of the size of several cell types, as well as pancreatic β-cell function and glucose homeostasis.

Active smoking is an established critical factor for epigenetic modifications in blood DNA [ 4].