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Comparison of early productive infection and infection with irradiated virus allowed us to dissect the contribution of the virion to changes in the cellular proteome.
The decrease in miR-34a expression correlates with the early productive phase and is attributed to the expression of HPV E6, which destabilizes p53, a known miR-34a transactivator.
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Based on the spatial location of Tyr1P in class I promoters, mostly found at the leading edge of Pol II in opposite orientation of the gene, it is tempting to speculate that this PTM might be involved in a transcriptional state marking the transition between early and productive elongation, providing a checkpoint for transcriptional complexes to proceed in productive elongation.
Daniel Doctoroff, the deputy mayor for economic development and rebuilding, told reporters yesterday that the mayor and the governor were having "early but productive discussions" about how the $1.3 billion would be spent.
I want to start my day early, be productive, drive results and leave to have dinner with my kids.
Expanding the Evidence Base to Drive More Productive Early Childhood Investment.
In the second quarter, the runs to Jacobs that had been so productive early were picking up less yardage.
Yanks blew a chance to really pour it on — David Waldstein (@DavidWaldstein) 13 Apr 12 The Yankees have been plenty productive early in games this season.
While the offense has been surprisingly productive early on, the Tigers would not have a winning record in the league without pitching.
The great musicians and singers of the Loser's Lounge will dive into the Roxy catalogue, concentrating on the band's productive early period (though Joe McGinty, the leader of the Lounge, says that "it will be hard to leave out 'Avalon' and 'More Than This'"), as well as the first four solo albums by Eno, landmarks of ambient pop.
The feasibility of rainfed agriculture in these semi-arid and arid areas may be greater in the temperate climates we examined here than tropical and subtropical areas, because in the temperate zone soil water storage during the cool season has the potential to support a productive early growing season despite limited overall precipitation45.
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Justyna Jupowicz-Kozak
CEO of Professional Science Editing for Scientists @ prosciediting.com