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Early attainment of male sexual maturity is associated with a variety of adverse effects including antisocial behaviors, short adult height, reduced fertility, and prostate and testicular cancer (Golub et al. 2008; Patton and Viner 2007).
The high, PSMA-dependant tumour uptake and the early attainment of high tumour to background ratio suggest that 68Ga-THP-mal-J591c-scFv can be used as a tracer for PET imaging of PSMA expression in PCa.
Continuous infusion of beta-lactams often also includes the use of a loading dose to ensure early attainment of target concentrations exceeding the MIC [ 63].
In all studies utilizing a continuous infusion mechanism of β-lactam delivery, a loading dose of the β-lactam was initially administered to ensure early attainment of fT>MIC.
It is also the first report to examine long-term remission by both ASAS PR and ASDAS ID criteria and the first to demonstrate early attainment of remission as a predictor of long-term and sustained remission.
Accordingly, it may reasonably be suggested that early attainment and maintenance of plasma trough concentration (Cmin) above the MIC should represent the goal of therapy in daily clinical practice for critically ill patients [ 5, 46].
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Feeding increased dietary fat from DDGS during the prepubertal growth phase did not negatively affect milk production, despite earlier attainment of puberty compared with other treatments.
The shorter (1.5 hours) half-life of CyC compared to creatinine accounts for the more rapid rise and the earlier attainment of a new steady state [ 20].
We hypothesized that earlier attainment of developmental milestones would be associated with better subsequent intellectual performance throughout the range of abilities, rather than confined to extremes.
Again there is no appreciable difference between the Northwest macro region (reference)—the area identified with the earliest attainment of very low fertility and the Northeast and the Center.
A critical site for lesion-induced hyperphagia and obesity in rats is also the MePD (36), which may explain the altered pubertal timing by way of an earlier attainment of critical body mass (37).
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