Sentence examples for Disruption of tolerance from inspiring English sources
Such a fragment may contribute to disruption of tolerance to fractalkine, resulting in an autoimmune response.
T-cell anergy and differential TCR signalling could thus also be key players in the disruption of tolerance and the onset of autoimmune diseases.
Provided that the minor allele of the studied CD40 variant decreases the efficiency of translation, this lower amount of CD40 would then result in a reduced induction of Treg, which would lead to a disruption of immune tolerance.
A combination of genetic factors and environmental triggers can lead to disruption of immune tolerance.
Vitamin D insufficiency, a common problem in apparently healthy elderly people, could lead to the disruption of immune tolerance and play a role in the development of chronic inflammatory disease and the autoimmune disorders often seen with aging.
In both Gram-positive and Gram-negative bacteria the disruption of bile tolerance loci often leads to impaired intestinal survival [ 14- 16], while a mutation resulting in high-level bile resistance of Escherichia coli results in a fitness advantage during intestinal colonization [ 17].
From an autoimmunologic viewpoint, disruption of self-tolerance is implicated through distortion in the cell-cell communications and cytokine networks.
Disruption of B cell tolerance in C4-/ anti-DNA transgenic mice.
Activation of Kupffer cells, oxidative stress, reduction in regulatory T cells, and the altered profiles of adipokines (leptin, resistin versus adiponectin) could also lead to the disruption of the physiological tolerance of the liver to portal antigens [3].
We then used LB media supplemented with different combinations of M9 salts to determine which of these ions was responsible for disruption of the acid tolerance response observed in LB medium (Figure 3).
The unique positioning of the liver at the juncture of the peripheral circulation and the portal circulation augments the interaction between naïve T cells and other hepatic cells and leads to the disruption in the development of tolerance to commensal bacteria and other environmental agents.
