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Once telomere uncapping occurs either endogenously at the end of cellular replicative lifespan or exogenously by reagents and conditions inducing telomere dysfunction, diminished amount and/or impaired activity of TRF2 results in ATM activation.
This can lead clinically to hypoglycemia or diminished amount of glucose in the blood.
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Western blot analysis of Mo-dp heterozygous brains showed diminished amounts of Atp7a protein, consistent with reduced expression due to the promoter region deletion on one allele.
A rare phenotype termed Kell null (Ko) is characterized by the absence of Kell protein and Kell antigens from the red cell membrane and diminished amounts of XK protein.
Stimulation of CD95 with anti-APO-1 in DMM-treated cells resulted in decreased amounts of FADD at the DISC and diminished amounts of procaspase-8a/b procaspase-8a/be CD95 DISC (Figure 7A).
So we have a diminishing amount going into the black.
In the aftermath of the 2008 recession, everybody was looking for ways to save and generally be smarter about using the diminishing amount of what they had.
As the product matures, becoming more standardized and better known, a diminishing amount of specialized knowledge is needed to sell it.
The market malfunctions have been assigned part of the blame for the diminishing amount of trading happening on the nation's stock exchanges.
Nursing home care will represent a diminishing amount of long-term care over all, with retirement communities, assisted living and home- and community-based options becoming more attractive alternatives.
The popularity of meal replacement drinks has been surging in the United States over the past few years, driven by the obesity epidemic and Americans' diminishing amount of leisure time, according to market research firm CB Insights.
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