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A possible explanation for the differences observed in these studies is the establishment of an insulin resistant phenotype that develops with aging [54].
In the current study, we investigated a mouse model of preclinical CADASIL (TgPAC-Notch3R169C), in which cerebral WM pathology develops with aging [ 17, 18].
Although leukoaraiosis develops with aging as a reflection of the burden of cardiovascular disease, many studies report a greater volume of leukoaraiosis in dialysis patients compared with age-matched controls [ 22, 23].
Benign hyperplasia (BH), which involves the proliferation of epithelial cells, commonly develops with aging and may increase the risk of breast cancer [ 2].
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Since frailty develops with ageing with decreases in many cardiovascular 4 6 and respiratory 4 6 parameters, further studies will be necessary to test the hypothesis that improvements in both respiratory function and cardiovascular autonomic modulation may counteract the development of frailty.
The verification of age effects is common in cognitive test validation, since cognitive functions can develop with aging and experience.
Thus, insulin resistance developing with aging even at the level of innate immunity could have antiinflammatory effects (Pickup and Crook 1998).
Although these findings established that vascular inflammation developed with aging in healthy adults, our results did not provide evidence that this inflammatory state was contributing to vascular endothelial dysfunction in older adults.
For developed nations with aging populations or developing nations investing in new programs, cross-country comparisons of health-care systems and their financing mechanisms are useful for containing health-care costs.
Whether this is a coincidence or other DNAJB6-myopathy patients will also develop FTD with aging remains to be seen.
And fleshing out strongly develops with age.
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