In this article we describe the assessment and control of lead dust exposure in the Treatment of Lead-exposed Children (TLC) Trial, a clinical trial of the effects of oral chelation on developmental end points in urban children with moderately elevated blood lead levels.
These assays measure biochemical, clinical, hematologic, histologic, neurologic, behavioral, reproductive, and developmental end points.
Doing so can provide earlier developmental end points at which to evaluate effects of contaminant exposure and help to identify mechanisms of contaminant toxicity to further explore.
However, effects on other developmental end points, including cognitive, attentional, and clinical mental disorders not measured in this study, cannot be ruled out.
Using a more extensive range of developmental end points, some studies of populations consuming seafood have reported associations with prenatal MeHg exposure, whereas others have found none.
She measured blood aflatoxin in more than 700 local children and compared the levels with a wide range of developmental end points.
We considered that the high demands in terms of data variation were more likely to be met with developmental end points that lend themselves to straight-forward quantification.
In addition to assessing dendritic morphology in these animals, we also quantified RyR expression and function, thyroid hormone levels, and developmental end points regulated by sex steroids.
Thus, it is also important to examine earlier developmental end points to fully evaluate the potential impact of atrazine exposure on individual and population fitness in amphibians.
