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We have shown that SALL2 is expressed in the developing human retina during the period of optic fissure closure and that Sall2-deficient mice exhibit an ocular coloboma phenotype providing a new model to investigate developmental closure and fusion mechanisms.
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Individual embryos shown vs. dorsal closure developmental time.
Furthermore, Utx Δ/Δ female mice and Utx Δ/UtyΔ male mice exhibited strong cardiac developmental and neural tube closure defects (cranioschisis) at day E9-E10.5 E9-E10.5
Filopodia can even drag whole epithelial sheets into alignment during the developmental morphogenetic movement, dorsal closure and also during wound healing (Jacinto et al., 2002; Millard and Martin, 2008).
Txnrd1 knockouts exhibited remarkable developmental, growth and neural tube closure retardation and embryonic death between E8.5 and E10.5.
Analysis of several litters and specimens per genotype was crucial in revealing highly localized differences in dynamic and variable developmental processes such as suture closure.
Neural tube closure is a critical developmental event that relies on actomyosin contractility to facilitate specific processes such as apical constriction, tissue bending, and directional cell rearrangements.
The Notch signaling pathway has not yet been linked to immune response or wound repair, but wound repair uses many of the same developmental pathways that function during dorsal closure in Drosophila development, which does involve Notch signaling [ 60].
Closure of carpels or angiospermy, a key developmental innovation, has been accomplished through different ontogenic routes among the flowering plants.
Specific closure of plasmodesmata is important for key developmental events, because of the water movement and/or diffusion of other molecules.
In mutant embryos, tissue junctions initially fail at the anterior end indicating inhomogeneous mechanical stresses attributable to head involution, another developmental process that occurs concomitant with the end stages of closure.
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