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The phrase "Despite knowing" is correct and usable in written English
It can be used to introduce a contrast between what is known and the action taken or situation that follows. Example: "Despite knowing the risks, she decided to invest in the volatile market."
Exact(59)
Despite knowing the outcome, it's never less than unbearably tense.
"Despite knowing that her ad is dishonest, Whitman continues to run it.
Despite knowing better, I continue to see people ignoring the lessons of diversification.
Despite knowing all that, when she shops online, she is still flummoxed.
Despite knowing little about what they were buying, executives at RBS seemed sanguine.
Despite knowing the risks, he had travelled to the isolated eastern town to deliver medical supplies.
Despite knowing nothing about the trade, she was fascinated by the process.
Despite knowing nothing about education or nutrition or charities, she set up Magic Breakfast in 2003.
Despite knowing from 2010-11 thAbbottott was going to win, social movements succumbed to the same old ineffective politics.
Despite knowing better, I just couldn't shake the feeling that with the right school supplies, she could rule the world.
Despite knowing that true illiteracy exists, I was still shocked to come upon it in real life.
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Since I tried Ludwig back in 2017, I have been constantly using it in both editing and translation. Ever since, I suggest it to my translators at ProSciEditing.

Justyna Jupowicz-Kozak
CEO of Professional Science Editing for Scientists @ prosciediting.com