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But unfortunately, these sequence-based prediction tools frequently do not consider specific off-target parameters like target site location, 3′′UTR conserved regions, and design specificity.
The most variable residues in the ATP pocket are targeted to design specificity into inhibitors in our various kinase projects.
Study design: specificity and sensitivity of HIV antibody assays were compared in matched serum and saliva samples obtained from 257 volunteers from a family planning clinic and from visa applicants, representing a low risk population (Group I), and from 52 volunteers known to be HIV infected (Group II).
These issues include: case reports, study design, specificity of exposure, interview or recall bias, misclassification of occupation or exposure, confounding multiple exposures, confidence intervals and statistical power, selection of relevant studies, consistency of study results, study cohort definition, cohort membership misclassification, dilution effect, and subcohort or stratified analysis.
With a deeper understanding of OTU DUB mechanisms, specificity, and additional structural insights, efforts to "design" specificity in OTU DUBs may generate enzymes with improved specificity and activity.
Along with the trend of 3D growth, modern cell laboratories strive to improve culture analysis platforms through size reduction and design specificity.
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The design specificities of the different types of IDs, as well as the results of the shimming and magnetic measurements performed at SOLEIL are reported.
The design specificities and goals of alternative splicing microarrays, in terms of identification and quantification of multiple mRNAs from one gene, are promoting the development of novel methods of analysis.
In the sequel, we present our classification, which aims at highlighting design specificities of the approaches.
After selection, a careful evaluation of methodological design specificities was performed in order to recalculate, whenever necessary, deletion rates using the most homogenous criteria.
Studies were divided between those reporting an association between gr/gr deletions and spermatogenic disruption/male infertility (9 studies) and those that did not (14 studies), followed by a pondered analysis of methodological design specificities.
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