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Both articles select a very limited number of trials, and share an important design limitation, namely, they compare clinical trials that recruit both MTX-naïve patients and MTX-resistant patients, which, from our standpoint leads to their results facing validity problems.
Unexpectedly, rpoS defects occur because of a basic design limitation in cellular regulation.
However, the excessive vibration of the DSF outer skins is a serious design limitation.
The main hurdle of such electrolyte in fuel cell is its higher operating temperature (1000 °C) which results in design limitation and higher fabrication cost.
On the other hand, the imposition of an a priori positivity constraint on the processing algorithm is a too strong design limitation.
The Authors encourage a shift in the current design paradigm: considering coupled nonlinear phenomena, and adequate modeling tools to support their analysis, from a design limitation to a design opportunity.
Similar(29)
On the whole, the numerous design limitations of the other studies limit their value.
Tape's inherent design limitations force some enterprises to artificially limit the size of their file systems, increase their filers and silo data to better meet backup deadlines.
It also moved to limit access to authentication and data, and set design limitations, aggravating developers who felt they had contributed to Twitter's growth.
Design limitations are also elaborated.
Implications and design limitations are discussed.
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Justyna Jupowicz-Kozak
CEO of Professional Science Editing for Scientists @ prosciediting.com