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This suggests that the cancer-related loss of asynchronous replication of SNRPN observed here resulted from delayed replication (due to cancer-mediated hypermethylation) of the normally early replicating paternal allele, rather than advanced replication of the normally late replicating maternal allele.
Altogether these observations clearly indicate that a common feature of CFS is delayed replication, substantiating the hypothesis that CFS are regions intrinsically difficult to replicate.
Gal-3 functions in host defense against C. neoformans more by interfering with fungal physiology through delayed replication, capsular binding, and vesicle disruption than by its effects on the inflammatory response.
These results suggested that the silencing of RBM24 stimulated the initial translation of HCV proteins but inhibited and delayed replication of HCV genome.
In contrast, selected antivirals had a better effect on delayed replication viruses (H1N1 and H1N1 SOIV).
It is generally agreed that fragile sites comprise regions of high DNA flexibility and display delayed replication [12], [13].
Similar(29)
Therefore, by delaying replication, Hog1 plays a key role in preventing conflicts between RNA and DNA polymerases.
The metrics used for comparison are throughput, Packet Delivery Ratio (PDR), end-to-end delay, replication overhead and offloading ratio.
When yeast cells are stressed during S phase, Hog1 promotes gene induction and, remarkably, also delays replication by directly affecting early origin firing and fork progression.
For example, within a minute or two of damage being inflicted on the genotype by ionising radiation H2AX labelling occurs at damage sites, checkpoints are instigated to delay replication and macroscopically discernable foci of proteins assemble around the break [34] [36] but it is not until tens of minutes later that the system responds with transcriptional responses [37].
Histone deacetylases (HDACs), particularly Rpd3, delay replication initiation (Knott et al. 2009; Vogelauer et al. 2002).
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