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On the whole, the inherently exploratory nature of the investigation framework introduced by this paper differs from the standard experimental procedures that rely on an a priori defined hypothesis to design a paradigm that addresses a specific cognitive process.
The alternative hypothesis for branchXsites tests of Yang, Nielson and colleagues (implemented in codeml) have fewer parameters than the unconstrained switching model implemented in fitmodel, and thus this approach may have more statistical power when one has well defined hypothesis for the branch on which switching is expected to have occurred.
However, targeted experiments involve the absolute quantification of a small number of metabolites (around 20 or less) to test a defined hypothesis.
Based on the already known data and ideas, conditions of progene formation can only be described as an approximate scenario rather than a clearly defined hypothesis.
Although both studies aimed at tapping different levels in the mental lexicon, the present paper explicitly investigated selection effects based on a neuroanatomically defined hypothesis.
The latter case would mean that more narrowly defined hypotheses reflecting the set of conditions imposed by each experiment could be true even if the original, more broadly defined, hypothesis described above were not true.
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The sample size was not defined on the basis of a pre-defined hypothesis testing.
That's a problem, because without a well-defined hypothesis it's hard to do any meaningful research - especially if, like Greenfield (a professor of synaptic pharmacology), the subject isn't really in your field.
The virtue of the mathematically-defined hypothesis is that it is clear and precise, and therefore susceptible to contradiction.
Based on this pre-defined hypothesis two latent factors coinciding with differences in cisplatin resistance between four ovarian cancer cell lines were easily identified.
Likewise, faculty members who oversee research activities that generate publishable data, often addressing a faculty-defined hypothesis using established protocols, could intentionally include exercises in student experimental design.
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Justyna Jupowicz-Kozak
CEO of Professional Science Editing for Scientists @ prosciediting.com