This high degree of conservation was further confirmed by experiments showing that E4orf4 mutants selected in yeast for loss of their ability to induce toxicity, were also deficient in their ability to induce cell death in mammalian cells [23].
The transformed MSCs approached tetraploidy, and were deficient in the ability to differentiate into adipocytes, yet had increased ability to become osteocytic.
These mutants were also deficient in their ability to stop DNA synthesis in NCI-H1299 cells [46], suggesting a link between competency to bind microtubules and ability to induce cell cycle arrest.
While teaching philosophy to undergraduates at Columbia University in the 1960s, Lipman saw that his students were passionate to change the world but deficient in their ability to reason soundly and exercise good judgment.
In a society committed to improving physical health (even toddlers know how to apply a bandage to a cut, he says), Winch explains that we're deficient in our ability to heal from emotional wounds.
The radB mutant was normal for gamma- and UV-radiation mutagenesis, it showed only a slight enhancement of gamma- and UV-radiation-induced DNA degradation, and it was ~60% deficient in recombination ability.
Current buildings' performance assessment tools are deficient in their ability to integrate and process building monitoring data to generate actionable information that can assist in achieving a higher level of building performance.
Such persons tend to show a great concern for efficiency, are overly devoted to work and productivity, and are usually deficient in the ability to express warm or tender emotions.
Mr. Prysby was also charged with misconduct in office for authorizing use of the Flint plant, "knowing that the Flint water treatment plant was deficient in its ability to provide clean and safe drinking water". Each of those charges carries a maximum penalty of five years in prison and a $10,000 fine.
For cells grown in rich medium, the radC mutant was normal for gamma-radiation mutagenesis, but showed less UV-radiation mutagenesis than the wild-type strain; it showed normal amounts of X- and UV-radiation-induced DNA degradation, and it was ~60% deficient in recombination ability.
