However, their clinical application is hampered by obstacles such as rapid corrosion, deficient antibacterial capability, and inadequate delivery efficiency.
Moreover, despite their apparently deficient transposition capability, MITEs are usually present in high copy numbers in many eukaryote genomes.
While limited resources had increasingly been channelled into "large capital equipment programmes", the forces had been left "critically deficient" in key capabilities such as intelligence, surveillance, communications, logistics and tactical transport.
Since one major reason cultured schistosomes rapidly acidify their medium is by the excretion of lactic acid [9], we hypothesized that the SmAQP-suppressed parasites were deficient in this capability.
Interestingly, these results strictly correlated with the parallel Cdc42 activation assays, showing that the same integrin-β1 mutant cell lines are also widely deficient in their capability to induce Cdc42-GTP production during C. jejuni infection.
We recently reported that PM2.5 exposure was associated with endothelial cell dysfunction in patients with type 2 diabetes and that factors such as obesity and an elevated HbA1c level, as well as deficient antioxidant gene capability (GSTM1 null), enhanced this deleterious association (Schneider et al. 2008).
However, this model is deficient in determining the capabilities of nodes and, configuration details, and the complete system has no backup, thus resulting in a single point of failure.
When further xenografted on athymic nude mice, PACE4-knockdown cells implant as tumors had significantly reduced growth rate and displayed deficient cell-cycle progression capabilities [ 7, 9].
For example, if a compound is bioactivated by phase 1 or 2 enzymes in vivo to a reactive metabolite before causing hepatotoxicity, then most HTS systems, which typically are deficient in these metabolic capabilities, will not be suitable for identifying these types of toxic events.
