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Mice with a severe HNF4α deficiency in the liver displayed reduced growth, altered glucose homeostasis and a postnatal lethal phenotype.
Indeed, Kim et al. have recently reported that mice with a deficiency in hepatic autophagy displayed induction of fibroblast growth factor 21 (FGF21), resistance to diet-induced obesity, and amelioration in insulin resistance.
Both ether lipid-deficient mouse models and human patients with ether lipid deficiency often display defects in myelination in both the central and peripheral nervous systems (da Silva et al., 2012).
Deficiency in Prader-Willi Syndrome Animal Models.
Deficiency in hypocretin is indicative of narcolepsy.
We report that the Δppk2 mutant displayed deficiency in several survival- and virulence-related phenotypes, which emphasizes a role for PPK2 in mediating stress tolerance and pathogenesis in C. jejuni.
Mice with bilateral striatal 6-OHDA lesions displayed deficiency in spatial recognition with short, but not long, delay (De Leonibus et al., 2007).
As anticipated, mice with an isolated deficiency in group IIA sPLA2 displayed substantial reduction of clinical signs of arthritis relative to congenic WT mice (Fig 4A and B).
Spc25c00064 homozygotes and hemizygotes (in trans over the deficiency Df 3R ry75) displayed an indistinguishable phenotype which was more severe than that of l(3 A34-1 hemizygotes.
Finally, Δgcn5 cells display a deficiency in the assembly of pre-replicative complexes.
Firstly, asymptomatic patients of NYHA I class display significantly deficiency in blood glutathione level compared to healthy controls.
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