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The results of this study are consistent with the growing body of evidence for the role of vitamin D deficiency in development of coronary atherosclerosis.
Together these observations suggest that the positioning of the maxillary alveolus and deficiency in development of the palatine plate contribute to the differences in the effects of the two FGFR2 mutations.
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Developmental psychologists study the progression of impulse control and delay of gratification over the lifespan, including deficiencies in development that are closely related to attention deficits and behavior problems.
To provide a preliminary investigation, we examined the visual cortex organization in the subgroup of subjects suffering from microphthalmia, a developmental deficiency in eye development that leads to the development of smaller (and in this case non-functional) eyes.
The follitropin receptor knockout (FORKO) mouse is a genetic model that leads to chronic estrogen deficiency early in development [ 99, 100].
Of note, CK depletion or impaired CK signaling leads also to vascular cambium deficiency later in development [ 32, 33] arguing for a similar role of CK in promoting cambium activity.
Since DLC1-deficient mice dies at embryonic stage, it would be interesting to see if hepatocyte-specific deficiency of DLC1 may predispose such mice to the development of HCC and to delineate the role of DLC2 deficiency in the development of HCC in these mice.
In conclusion, this study has strengthened the evidence for the role of vitamin D deficiency in the development of coronary atherosclerosis, especially during the early events leading to development of coronary calcification.
Mice deficient in the Il4 gene have low IgE levels, deficiency in the development and maintenance of Th2 cells, and an attenuated allergic airway inflammation in murine models [3], [4].
Despite the growing evidence suggesting a role for vitamin D deficiency in the development of IBD, the exact role of vitamin D in IBD is still unclear and merits further investigation.
Although recent investigations of GA signaling have focused on the consequences of GA deficiency in stamen development, over-activation of GA signaling also negatively affects silique fertility in Arabidopsis (Plackett et al. 2014).
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Justyna Jupowicz-Kozak
CEO of Professional Science Editing for Scientists @ prosciediting.com