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Daily adherence was calculated as average daily adherence (100 × capsules taken/2), with overall adherence calculated as the average daily adherence.
Daily adherence during the intake periods of each cycle was generally lower compared with daily adherence calculated on the basis of drug intake plus rest period.
Daily adherence was not associated with sociodemographic and disease-related factors.
Daily adherence was defined as percentage of days with correctly administered capecitabine doses and assessed using medication event monitoring.
Daily adherence to study treatment was tracked using both electronic as well as self-reported written logs.
Daily adherence to therapy was calculated as the ratio of capsules taken on that day to capsules prescribed by the protocol (i.e. 100 × number of capsules taken on that day/2).
The binary variable of daily adherence, non-adherent versus adherent, was transferred into a relative variable.
A participant was classified as initially adherent (baseline daily adherence ≥90%) or initially non-adherent (baseline daily adherence <90%).
One study arm consisted of patients classified as initially adherent (baseline daily adherence ≥90%), the other arm of initially non-adherent patients (baseline daily adherence <90%).
Throughout all cycles, median daily adherence of initially adherent patients was 100.0%.
Median daily adherence of initially non-adherent patients increased from 85.7% to 97.6% during the observation period of six cycles.
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