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DNA shape changes in response to cytosine methylation could be a general mechanism for modulating protein DNA interactions.
DNA shape, particularly the width of the minor groove, has been proposed to play a major role in the specificity of Hox binding as the N-terminal arm of the homeodomain makes specific electrostatic contacts within the minor groove [ 22, 23].
The DNA shapes, for example, could be used to more precisely locate the gold nanoparticles that would then be used to grow nanowires.
That could one day lead to an application in which such DNA shapes could be used to create a scaffolding just as wooden molds are now used to create concrete structures.
Computational tools to aid the design of compatible DNA shapes and the structure assembly assessment are presented.
For 9C14, efficient LacI-induced energy transfer (∼74% based on donor quenching) confirms that the designed DNA shape can force the looped complex into a closed form.
In this study, the plausibility of the approach is validated using the formation of multiple 3 × 4 DNA network fabricated from five basic DNA shapes with distinct configurations (monomino, tromino and tetrominoes).
Through the analysis of whole-genome sequencing data, our findings shed new light on the molecular genetics of uveal melanoma, delineating it as an atypical tumor of the adult for which somatic events other than mutations in exonic DNA shape its genetic landscape and define its metastatic potential.
Specific and non-specific DNA binding proteins recognize sequence-dependent DNA shapes [5].
We also observed an interesting connection to DNA shape.
larger changes but DNA shape of helix intact?
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CEO of Professional Science Editing for Scientists @ prosciediting.com