Sentence examples for DNA sequence alteration from inspiring English sources
These observations support the hypothesis that genomic diversity driven by mutation or DNA sequence alteration and environmental adaptation may impact S. cerevisiae strain diversity more than geographical origin.
All cancers demonstrating mobility shifts on single-stranded conformation polymorphism suggestive of DNA sequence alteration were subjected to definitive DNA sequencing of the relevant portion of the estrogen-receptor gene.
Epigenetics describes mechanisms of mitotically heritable changes in gene expression that occur via means other than DNA sequence alteration.
However, in most of the BWS cases with methylation abnormalities, no DNA sequence alteration has been identified so far.
In order to examine these mechanisms, we investigated the involvement of epigenetics, the mechanism of heritable changes in gene regulation without DNA sequence alteration.
The second type, described here as a "secondary" constitutional MLH1 epimutation, is caused by a cis-acting DNA sequence alteration, and therefore displays a Mendelian inheritance pattern.
Molecular genetic studies of lung cancer have revealed that clinically evident lung cancers have multiple genetic and epigenetic abnormalities, including DNA sequence alterations, copy number changes, and aberrant promoter hypermethylation.
Our view of the abnormalities required to generate and sustain leukemia is evolving from a piecemeal account based on individual lines of research into a comprehensive view of how all the important components (eg, transcriptional program, chromatin modifications, DNA sequence, alterations in noncoding genome) interact, in each patient and each leukemic cell.
We sequenced all eight SDHB gene exons in 16 leukemic cell line DNAs, including those derived from T, B, NK cells and monocytes, and found novel expressed DNA sequence alterations in two of six childhood T-ALL cell lines.
For this reason, we further interrogated the TCGA database for DNA sequence alterations in PTGS pathway genes.
Homologous recombination allows a wide variety of DNA sequence alterations to be made at or near the break site.
