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Among the therapies on the continuum are organ transplantation (for genetic-deficiency diseases); vaccination (which precipitates irreversible changes in white blood cells' DNA, initiating the synthesis of antibodies); and drugs (to stimulate the activity of dormant genes in sickle-cell anaemia).
RAD51 binds to the 3′ end of DNA, initiating DNA polymerase and repairing the damaged sites.
HCAs can directly damage your DNA, initiating cancer.
Lack of balance between the amount of meat and fruit, berries and vegetables may lead to the accumulation of damaged DNA, initiating DNA instability and inducing cancer development.
Because the duplex DNA probe can be stepwise removed by Exo III, the target DNA is released and hybridizes with another fluorescently labeled DNA, initiating the next round of cleavage.
Since the formation of triplex DNA implies a sharp bend in the DNA molecule, these observations predict a functional model that is consistent with a duplex-strand separation mediated by the TCC-repeat motif that does not end in recombination or chromosome break but fold back the DNA initiating a loop configuration that brings together both targets.
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Then the released initiator DNA initiated another autocatalytic strand displacement reaction.
Kripke, M. L., P. A. Cox, L. G. Alas, and D. B. Yarosh (1992) Pyrimidine dimers in DNA initiate systemic immunosuppression in UV-irradiated mice, Proc.
We are using transgenic and knockout mouse models to examine whether stabilization of B7h by TLR9 is an important molecular mechanism by which CpG DNA initiates autoimmune antibody production.
The viruses can be readily manipulated, accommodate large insertions of foreign DNA, initiate little to no microscopically observable cytopathic effect in mammalian cells and have a good biosafety profile.
Both transfected dsDNA and viral DNA initiate the synthesis of cGAMP that binds to STING and initiates IRF3 activation and interferon production.
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