Rapid technological changes, coupled with cultural diversity and employee mobility, have created the milieu for critical issues in organizational training methods.
9– 12 In addition, CAFs have recently been reported to function as modulators of immune systems through secretion of transforming growth factor-β (TGF-β) and other immune suppressive cytokines, creating the milieu in which antitumor immune responses are impaired.
For example, although it is clear from the literature that seronergic, channelopathic, immunologic, metabolic, and nicotinic mechanisms play a potential role in modulating SIDS risk to varying degrees, it is still unclear which combination of variants creates the milieu that reasonably predicts SIDS risk.
"You've got to stabilize the patient's interaction with family and try to create the best milieu for the patient to be able to return to employment, stay with the family and return to self-respect".
Epigenetic changes, cellular signaling and humoral pathways create the cellular milieu and pathophysiological profile, depending on the timing, disease setting, and stimulation state.
Ideally, the quantities of TGF-β and IL-10 produced should be large enough (but not overly large) to create the immunosuppressive milieu.
In these cases, inflammation caused by food could create the pro-inflammatory milieu necessary for the induction of migraine by other triggers.
The Coen brothers re-create the sixties milieu with a disabused fascination, and their portrait of a great man trapped in a mediocre career delivers straightforward pathos with an ironic sting; as ever, their best joke is a cosmic one.
Dark, gloomy sky, frigid blowing southern winds, poor visibility and a temperature nearing negative 20 degrees centigrade created the requisite milieu for such a mental state.
As celebrity actors, producers and entrepreneurs, they helped create the famed Second Avenue milieu that reflected and refracted the fears, anxieties and longings of the newly arrived.
Both mark the initial site of mesoderm formation by epithelial-mesenchymal transition (EMT) and, thereby, create the 'milieu intérieur' (Bernard, 1859) as the basis for all internal organ anlagen.
