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In addition, we recently reported that Fgfr2C342Y/+ mice on a BALB/c genetic background have diminished cranial bone volume and density when compared to wild type mice [ 5].
Abnormal BMP signaling in neural crest cells was also recently shown to cause diminished cranial bone volume and density in combination with craniosynostosis [ 44].
Cranial bone is a complex material comprising of a three-layered structure: external layers consist of compact, high-density cortical bone and the central layer consists of a low-density, irregularly porous bone structure.
Cranial bone repair is one of the oldest neurosurgical practices.
Aberration is particularly annoying during imaging within the skull because of the various thicknesses and densities of cranial bone.
Recently, skeletal survey showed the presence of osteopetrotic radiological signs including generalized increase in bone density (Fig. 1b right panel), cranial sclerosis particularly at the skull base (Fig. 1a bottom), widening of anterior ribs and long bone metaphysis, Erlenmeyer flask deformity of distal femurs and suggested "sandwich vertebrae" (Fig. 1c).
We recently reported that cranial bones of Fgfr2C342Y/+ craniosynostotic mice are diminished in density when compared to those of wild type mice, and that cranial bone cells isolated from the mutant mice exhibit inhibited late stage osteoblast differentiation.
Deb's bone density stinks.
Their bone density appears poor.
Also bone density.
A review of hedgehog signaling in cranial bone development.
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