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Exact(8)
"Starting in children may prevent the disease process developing if we correct the basic defect early in life.
Understanding how CFTR mutations translate to disturbed synthesis or function of the CFTR protein has opened the way to 'personalized' treatments to correct the basic defect.
Other mutation type-specific treatments under clinical investigation are premature stop codon-read through drugs and antisense oligonucleotides that correct the basic defect at the mRNA level.
A clinical method for detecting changes in airway liquid absorption could provide a means of screening medications designed to correct the basic defects of CF lung disease.
Prof Stuart Elborn, who led the European part of the trial from Queen's University Belfast, told the BBC News website: "This is very exciting and it really demonstrates that we can correct the basic defects in cystic fibrosis.
There are currently 2 very different approaches that aim to correct the basic defect: gene therapy, aimed at correcting the genetic alteration, and therapy aimed at correcting the defect in the CFTR protein.
Similar(51)
Sweat chloride concentration, a biomarker of CFTR function, is an appropriate outcome parameter in clinical trials aimed at correcting the basic CF defect.
The recent development of CFTR-targeted drugs that emerged from high-throughput screening and are capable of correcting the basic defect promises to transform the therapeutic landscape from a trial-and-error prescription to personalized medicine.
Bootstrap 632 is a variant, which tries to correct the bias of the basic bootstrap estimator by performing an average with the resubstitution estimator [25]: (9).
But they say that he and his successors have tried in good faith to correct the problems and that the basic story holds up.
"We have the basic duty to correct the mistakes we have made over the course of five decades of building socialism in Cuba".
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Since I tried Ludwig back in 2017, I have been constantly using it in both editing and translation. Ever since, I suggest it to my translators at ProSciEditing.

Justyna Jupowicz-Kozak
CEO of Professional Science Editing for Scientists @ prosciediting.com