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As a core checkpoint component in the mitotic cell cycle, the accurate roles of Bub3 in meiosis are little known.
A recent search in PubMed for just one of the core checkpoint proteins, BUB1, returned 583 documents.
The BUB1B protein interaction network based on our text and data mining results is shown in Figure 2. Five of the seven core checkpoint proteins MAD1L1, MAD2L1, BUB1, BUB3 and MPS1 are linked directly or indirectly to BUB1B via interactions we identified by text mining.
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Of the core spindle checkpoint proteins, three BUB1, MPS1 and AURKB are protein kinases (3).
We conducted our initial analysis on the core spindle checkpoint proteins BUB1, BUB1B and MAD3.
Moreover, the induction of germ cell death by DPE plus UVA was alleviated in single-gene loss-of-function mutations of core apoptotic, checkpoint HUS-1, CEP-1/p53, and MAPK dependent signaling pathways.
Together with the Mps1 kinase (Winey et al. 1995; Weiss and Winey 1996) Mad1, Mad2, Mad3 (Bub11), Bub1, and Bub3 form the core spindle checkpoint components that inhibit the APC– Cdc20 in response to the presence of unattached kinetochores.
As a core member of checkpoint proteins, the individual role of Bub3 in mammalian oocyte meiosis is unclear.
The M19 module contains core cell cycle checkpoint genes such as CCNA2, E2F2, and MCM3, whereas the M5 module includes genes such as ANLN, PRC1, and RACGAP1, which are mostly involved in cytokinesis.
To save the time of communication between host and disk, the portable operating system interface (POSIX) thread is utilized to create the other CPU core at the checkpoints.
The first was MAD1, a core component of mitotic checkpoint, discovered in his lab in 1998.
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