Considerably altered in the 20th century by water-control projects, they join to form the Euphrates at Keban, near Elazığ, where the Keban Dam (completed 1974), spans a deep gorge.
However, FGF-2-dependent complex formation between δEF1 and CtBP1 mutants with alteration of these phosphorylation sites (100, 144, 158, and 176) was not considerably altered, compared with that between δEF1 and CtBP1 (Supplementary Figure S3D).
The original Green Line has since been considerably altered on the ground, with cataclysmic consequences for people on both sides.
During the forming process both geometry and mechanical properties are considerably altered.
In sharp contrast, mutants of Asp167 showed considerably altered specificity profiles.
The building, considerably altered, now houses part of the National Maritime Museum.
The terrorist attacks have considerably altered the profiles -- and power -- not just of President Bush but of many of this nation's other leading political and governmental figures.
Thus the capacitance of the oxide films of alloys seems to be considerably altered during the barrier layer dissolution process.
When Vail reaches 50, much of its 1960's aesthetic of a Bavarian hamlet along an interstate will have been considerably altered.
The Trust said those rooms had been "less architecturally significant and had been considerably altered over the centuries".
In Morocco, as is common throughout the western Mediterranean region, centuries of human activity have considerably altered the natural vegetation.
