So far, candidate-gene approaches have provided the most convincing evidence for the action of natural selection on particular genes, particularly when functional evidence is also available, despite the bias inherent to such approaches due to the need to make assumptions at the outset concerning the genes likely to be subject to selection.
Since the constitution was of foreign origin, it was a source of controversy from the outset, specifically concerning the Emperor's role and Article 9. Besides, Shintô and the state were clearly separated, and Yasukuni Shrine too was made independent from the state, and has since been privately funded.
This time, the application process was very difficult - the staff were very sceptical - and we were concerned from the outset.
Crichton was concerned from the outset with how to give a distinct look to the gunslinger's point of view when the audience saw events through its eyes.
It was apolitical and middle-class to its soft core, and was concerned from the outset with love not war, flowers not favelas.
However, having also been seen her bullied because of her eccentricities, I am concerned from the outset that this program, Auti-Sim, does not render her life experience as freakish or weird.
Jamison is concerned from the outset that her book will not escape "the tedious architecture and tawdry self-congratulation of a redemption story"—that it will, in short, be boring.
The committee then decided on the subjects to be depicted and, in discussion with the stained glass artist, agreed on the details of the design; Scott was concerned from the outset that "the windows should not detract from the architecture".
Another advance concerns the drawing (at the outset) of the households themselves and involves random-digit dialing with atypical use of list-assisted sampling.
I'd had my concerns at the outset, of course.
If we had, current procedures would have identified concerns from the outset as this involved potentially identifiable and sensitive information".
