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Because of the high computational cost of MM/GBSA, particularly the GB calculation, the use of MM/GBSA as a scoring function to rank thousands to even millions of docked conformations is computationally unaffordable.
Whereas in the (linear) SI case matrix inversion can be efficiently done in the Fourier domain (eigenvalues/eigenvectors of the convolution matrix), obtaining the eigenvectors and eigenvalues of an arbitrary square SV matrix of a large size is computationally unaffordable in most situations.
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Make college education unaffordable.
That could be unaffordable.
Unaffordable funerals?
Republicans insisted an expansion was unaffordable.
Now it has an unaffordable borough, Manhattan.
It does include unaffordable tax cuts.
The whole became unwieldy and unaffordable.
Opponents label it an unaffordable boondoggle.
Health care is distant and mostly unaffordable.
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