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The formulae for these distributions are often very complex and computationally problematic.
The exact distributions of the number of runs and patterns are often very hard to obtain or computationally problematic, especially when the pattern is complex and n is very large.
One-stage method in which interactions are tested using all samples at one time may be computationally problematic, may have low power as the number of markers tested increases and may not be cost-efficient.
Currently, the applicability of macroscopic Dynamic Network Loading (DNL) models for large-scale problems such as network-wide traffic management, reliability and vulnerability studies, network design, traffic flow optimization and dynamic origin destination (OD) estimation is computationally problematic.
Highly detailed air transportation models can be over determined and computationally problematic.
Of course, since maximal cliques have to be found in order to build the k-clique communities, this method can be computationally problematic [ 19], although in practice it performs very well.
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These deaths can be applied to everybody or (computationally more problematic but biologically more realistic) to newborn babies only (Martins and Cebrat, 2000).
Although single-protofilament models can explain many experimental observations and are computationally attractive, they are problematic for not taking into account lateral bond interactions.
The method makes maximal use of the available genotype data, is computationally efficient via use of matrix algebra and does not depend on problematic solutions such as imputation.
Using a similar method to count the number of activated transport reactions is problematic as it requires k· n additional Boolean auxiliary variables, which is computationally intractable.
Although these extensions are computationally effective, the particular implementation and interpretation of the additional terms and the corresponding constitutive parameters is problematic.
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Justyna Jupowicz-Kozak
CEO of Professional Science Editing for Scientists @ prosciediting.com