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Computational pathway analysis indicates that a number of the metabolic pathways are disrupted due to pseudogenes.
A computational pathway analysis revealed that this design would potentially enable a lysine yield of 0.9 mol mol-1, providing room for further development.
We will discuss issues related to knowledge representation, and to the capture of underlying biological complexity, from the perspective of computational pathway analysis.
Proteins were quantified by spectral counting and potentially perturbed molecular pathways were found with Ingenuity Computational Pathway Analysis (IPA; QIAGEN, Redwood City, CA, USA).
ReTrace is a recent computational pathway analysis method [ 21], which can be queried to discover branching metabolic pathways in a universal metabolic database.
He co-leads a Genome Data Analysis Center for the TCGA project, co-chairs the pan-cancer TCGA effort, is a leader of the bioinformatics pathways group for the International Cancer Genome Consortium (ICGC), and directs the computational pathway analysis for a Stand Up To Cancer (SU2C) Dream Team to identify therapies for resistant prostate cancer.
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Clustering was performed using log2 ratio (red/green) and selected genes were subjected to bio-computational pathway analysis (as described in Section 2) that revealed involvement of genes in three pathways: canonical Wnt signaling (Fig. 1a), Ras/MAP kinase (Fig. 1b) and cell adhesion (Fig. 1c).
Mathematical models and bioinformatics platforms that perform high level computational integrated pathway analysis may reveal clinical relevant signaling pathways amenable for targeting in individual patient tumors.
This model includes multiple types of -omic data and novel computational tools for pathway analysis and functional investigation of variants of unknown significance alterations.
XL conducted the computational analysis and pathway analysis.
Using a computational tool, Ingenuity Pathway Analysis (IPA), we were able to build networks of interacting genes from the PRG list.
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