Paul G. Allen, who founded Microsoft with Bill Gates but left the company years ago, also had considerable setbacks in his investment portfolio this year.
The 12 years that passed between her two encounters with "Sight Unseen" brought her great success, but also considerable setbacks, neither of which she could have imagined at the time she was first cast.
With new information from a reporter on the front lines, it reported instead something far less optimistic: that allied forces had faced considerable setbacks in Karbala, about 70 miles south of Baghdad, and could even be undermanned there.
Given that entrance requirements at the Grand École were not particularly high, the rejections were considerable setbacks.
In view of these considerable setbacks with the use of SARM KO mice, we strategically planned and developed a novel in vivo adoptive transfer mouse model system to study the effect of SARM knockdown during an experimental influenza infection.
That was always going to be a considerable setback.
That was a considerable setback for an unelected, already unpopular President like Truman.
John Terry, nursing a sprained ankle, would probably not have started anyway, but Hazard's absence represents a considerable setback.
THE cause of serious eating in Bergen County suffered a considerable setback in 1999, when Jamie Milkman left Jamie's, his namesake restaurant in Englewood Cliffs.
The absence of their captain would be a considerable setback for City given that they will also be without the suspended Yaya Touré and the latest bulletin on David Silva's knee injury indicates he might not be fully fit either.
The loss of the Lions duo is a considerable setback for Irish coach Joe Schmidt before the eagerly anticipated Aviva Stadium game against the All Blacks.
