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This again justifies our approach to insist on comprehensive loci coverage across the whole HLA region instead of only focusing on certain "promising" loci.
While the advantages of big sample size and good genotyping resolution are self-evident, the importance of comprehensive loci coverage can not be over-emphasized.
Once these more comprehensive loci had been built, we added GO-term associations from Nasoniabase (21) and ensembl (24).
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Because of the comprehensive locus coverage, we uncovered that the association signal from HLA-DQB1*05:02 was secondary to its LD with HLA-DRB1*16:02.
Based on the experimental investigation, a theoretical analysis was developed to predict the dynamic response of sandwich panels by employing a comprehensive yield locus and a modified classic monolithic panel theory.
Comprehensive single locus and haplotype analyses were performed and revealed several interesting results in both maternal and fetal data.
In other species, integration of independent mapping populations has enhanced genetic resolution and provided comprehensive relational locus information for disparate marker and population resources [ 32].
We used data from the D. suzukii genome to conduct a comprehensive multi-locus phylogenetic and dating analysis in the context of genome data from 20 additional Drosophila species.
The comprehensive multi-locus phylogeny of Metzgar et al. [ 32] has recently been interpreted to fully support a separate generic status of Osmundastrum as suggested earlier by Yatabe et al. [ 31].
To obtain insights into the genetics of popping ability related traits of nuña bean, a comprehensive quantitative trait loci (QTL) analysis was performed to detect single-locus and epistatic QTLs responsible for the phenotypic variance observed in these traits.
And just this week a paper in Psychiatric Genetics, on a single glutamate-related gene, GRM3, has shown it is connected both to schizophrenia and depression, and also to alcoholism.It will therefore be interesting to repeat the approach this study used to try to create comprehensive lists of loci for these other conditions.
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