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How feasible it is to generate large enough annotated text data sets for complex annotation types at various levels of granularity is still unclear.
For each pair, we look for other evidence of interaction between the two proteins using complex annotation from [ 40], and also examine whether the two proteins are annotated as interacting in BioGRID using other experimental methods.
This introductory tutorial shows how to load a catalog, basic interactions, and how to generate complex annotation schemes.
In practice, more ambiguous cases can occur and, ultimately, the decision of the labeler has an arbitrary component, as in every complex annotation process.
The complex annotation of proteins was also downloaded from CYGD [27], and the pathway annotation of proteins was retrieved from KEGG [29] (Kyoto Encyclopedia of Genes and Genomes) (see Table S3 and Table S4).
Secondly, it is possible to synthesize and analyze complex annotation concepts.
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This feature makes a compound graph suitable for subpathways and molecular complex annotations in biological pathway representation and is useful for managing complexity by interactively dividing a pathway into distinct components or modules (5, 14).
The catch is that to get the full benefits of the type checker, the programmers have to add complex annotations to their code.
With his left hand he formed the lopsided bass-clef vamp of a piece called "Avenging Angel"; with his right he improvised complex annotations, firing them off in boldface or sleek cursive.
This standard was designed to allow arbitrarily complex annotations of the entities that are crucial to phylogenetic statements.
Additional protein complex annotations based on consensus across different studies were obtained from Benschop et al. 2010, [ 72].
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