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Complete in vivo conversion of ARS into DHA was assumed and the administered dose of DHA was calculated by adjusting for the difference in molecular weight.
Complete in vivo conversion of artemether into dihydroartemisinin was assumed, and the administered dose of dihydroartemisinin was calculated using the relative difference in molecular weights.
Complete in vivo conversion of oseltamivir into oseltamivir carboxylate was assumed, and the administered dose of oseltamivir carboxylate was calculated using the relative difference in molecular weight.
While the administered dose was 8.25 GBq, of decay energy.
The maximal administered dose was 3600 mg.
The administered dose represented an overdose.
The administered dose is worth of attention.
STX was excreted only by urine; within four hours, 25percentt of the administered dose at 2.7 mg/kg and 10percentt of the administered dose at 10 mg/kg.
Because activities related to preparation and administration of Dose 2 were assumed to be the same once Dose 1 preparation was completed, all simulations were conducted and analyzed based on the steps a parent would complete in order to administer Dose 1 and Dose 2 of each pen device.
The scenarios included tasks that required: selecting the correct pen (900, 450, or 300 IU) and administering a starting dose, adjusting a treatment dose, completing a partial dose using a second pen, resetting a dose on a pre-used pen, and recognizing that one pen fully dispensed will not complete the dose and that a second pen is needed.
Hematological toxicity was dose limiting and correlated with the administered 131I dose.
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