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Clinical adjudication classified 105 cases as definite (10), probable (31), or possible (64) ARC stent thrombosis.
Clinical adjudication: utilises the criteria set out in the Prevalence Survey of Healthcare-associated Infections 19 to conclude and summarise the clinical opinion regarding each suspected infection episode.
Both cutoffs (0.3 and 2.0) were subsequently validated in a 23 site study of 408 critically ill patients in the USA (Topaz study) using clinical adjudication to determine the primary endpoint of moderate severe AKI [231].
Overall accuracy was 87% (238 of 273 concordant with clinical adjudication), which was more accurate than procalcitonin (78%, P < 0.03) and three published classifiers of bacterial versus viral infection (78 to 83%).
More recently clinical adjudication has begun to be relevant and appeared in the AKI literature [ 10, 14, 15, 30].
This end point has traditionally been difficult to ascertain in observational registries because it requires clinical adjudication and is not captured by administrative coding.
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Patients, investigators, and the independent clinical event adjudication committee were blind to study group assignments.
All clinical data adjudication was made by trained cardiologists to most accurately evaluate the presence of SCD.
Chest X-rays were interpreted independently by two physicians blinded to the clinical variables, with adjudication of disagreements.
We also thank the members of the cardiac and neurologic adjudication clinical expert committees.
In the linagliptin clinical trial program, adjudication of hospitalization for CHF was implemented during phase 3b.
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