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If significant changes in mass balance are observed, additional biological insight will be needed to check the pathway model and identify possible sources of leakage or gain of mass.
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15 Next, we checked the pathways significantly enriched in OPCs in vitro and in vivo and found that only the cell cycle pathway was identified by both GAGE and SPIA (Supplementary Table 16).
Detailed information regarding species used and orthologous sequences is given in the Supplementary Sheet 3. Further, we checked the pathways in which these common transcripts might be involved using DAVID and found that they mainly related to oxidative phosphorylation, ribosome biogenesis, and cardiac muscle contraction.
Some operators remove the packs while the catheters are still in the arteries, check the nasal pathway for bleeding, and finish the procedure if the nasal pathway remains dry for 15 min.
Information from the literature was used to close gaps in the metabolic pathways, include pathways specific to A. baylyi that were unknown to the metabolic databases, and check the predicted pathways, for instance for the specificity of the cofactors.
Entropy age relationship was studied to check the pedogenetic pathways responsible for soil landscape evolution.
We have used pathway related data of Arabidopsis thaliana from KEGG and AraCyc to check the consistence between pathway and our network for the validation of our interactome.
In order to check the robustness of the pathway activity patterns in relation to the intrinsic subtype classification, we asked whether the identified modules showed the same pattern of variation in external independent cohorts.
We also checked the Consensus Pathway database with the same genes (see Additional file 4: Table S1).
We found there are some gaps in C4GEM when checking the xylose pathway in the two networks.
Taking the high redundancy among these pathways in the Ingenuity database into account, we checked the individual pathways for redundancy.
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