However, with this reasoning, we would expect that the weaker hydrogen bonds for A/T pairs would cause paired strands rich in A/T nucleotides to dissociate more frequently than paired strands rich in G/C nucleotides, providing more opportunities for A/T rich sequences to undergo slippage-induced mutations.
Likewise, low quality bases (threshold set as a minimum average of phred 20 for this study) could cause pairs to evade detection.
These four comparisons were limited to survivors, which caused pairing to be broken.
In this construct, the epitope is less constrained by the flanking linker regions and is positioned so that the symmetry of the shell causes pairs of epitopes to come close enough to interfere with one another.
IP6 binds to a novel 'allosteric' surface on the PH-TH domain that is separate from the canonical PIP3-binding pocket; this binding causes pairs of Btk enzymes to form dimers, which leads to activation.
In particular, although the HRC and motion energy models differ in terms of their intuition and neuronal bases, both models rely on the same mathematical fact about moving visual stimuli motion causes pairs of spatially separated points to become correlated when a stimulus moves from one location towards the other (Adelson and Bergen, 1985; van Santen and Sperling, 1985).
PRE-containing fragments, which coincide with localized presence of Pho in chromatin immunoprecipitations, were shown to maintain restricted expression of a lacZ reporter gene in embryos and to cause pairing-sensitive silencing of the mini- white gene in eyes.
In case of Palladium II -complexes (6-8), the isatinic hydrazone Palladium II -complexestrong enough to cause spin pairing.
The ligands tending to give a strong field and to cause spin pairing give 4- or 5- rather than 6- coordinate complexes.
Nevertheless, despite these problems that may cause mis-pairing of non-orthologous promoters, as much as 82% of the promoter pairs were shown to be evolutionally related in the data set.
