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Causative therapy of ochronosis must aim to reduce the creation of harmful BQA.
There were patients who received either empirical or causative therapy.
Unfortunately, Sneddon's syndrome is a progressive disease and no causative therapy is yet known.
In this study, we developed the basis for a causative therapy aiming at the delivery of the enzyme to the inner site of the keratinocytes' plasma membrane.
As MAS is a condition with parenchymal damage, pulmonary hypertension and obstructive airway disease, no simple causative therapy is possible.
Previously, early liver transplantation was the only causative therapy in TTR-FAP (Holmgren et al., 1991; Reilly, 2005).
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Causative therapies for this complex disorder face major hurdles, and clinical implementation remains elusive.
Ultimately, the defined molecular profiles may identify individuals at risk early in life and may serve as a guidance to administer personalized interventions for causative therapies and/or early targeted prevention strategies.
The diagnostic value of measuring even early nerve injury may include earlier initiation of established causative therapies, but also earlier recognition of beneficial effects in clinical intervention studies.
We focused on relevant urologic history (UH), radiological findings (RF), need of urologic procedures, causative organisms, antimicrobial therapy (AT) and patients' outcomes in the ICU.
Causative with Stimulus-subject.
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