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No causative lesion was identified (Fig. 1).
The causative lesion can be precisely identified and the patency of outflow vessels can be restored.
When a causative lesion other than vascular compression is demonstrated, a diagnosis of "symptomatic TN" is made [1].
The importance of the pathological heterogeneity of focal and diffuse TBI lies in the fact that patients with the same GCS score can have markedly different treatments, recovery patterns and outcomes depending on the causative lesion.
Fosmid rescue with a 38-kb genomic region (WRM0636bB07) containing F35B3.5a (ptrn-1; a.k.a. cspr-1 and pqn-34) suggested the lesion in this gene was the causative lesion resulting in the axon overgrowth phenotype.
This paper provides a review of the visual pathway and, from the clinical population, profiles visual field loss in terms of type and extent of visual field loss, site of causative lesion, the treatment options, and outcome.
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The condition has been recently recognized in the current International Classification for Headache Disorders (ICHD-III beta) as an intraoral burning or dysaesthetic sensation, recurring daily for more than 2 h per day over more than 3 months, without clinically evident causative lesions.
Abscesses were considered cryptogenic in origin when no causative lesions were apparent.
Moreover, the causative lesions in epilepsy might be missed by 1.5-Tesla MRIs, especially performed in the early 1990s.
These analyses did not reveal any other potentially causative lesions except the original one the p.Gly223Ser in GCK.
Finally, casting a wide net to identify the causative lesions by using whole-genome sequencing may be cost-and labor-intensive and limited by lower depth of coverage.
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