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This study demonstrates that the PLSR imputation method can efficiently impute missing genotypes from LDP to HDP.
Additional analyses assessed ACR response using mixed model repeated measures (MMRM) imputation; the individual components were imputed using MMRM prior to calculation of response.
This was in contrast to the WOMAC imputation method, whose ability to impute was dependent on the rate of missing values.
Each of the 500 full-covariance spectral CGs is used to impute clean speech with six iterations of the MAP imputation.
Accurate imputation of SNP with rare alleles (MAF ≤0.05) is important especially when the imputed genotypes are to be used in association studies.
The study also compared the proposed imputation approach with mean imputation and other three KNN imputation approaches.
The relatively optimal fixed parameter settings for KNN imputation for software quality data is also determined.
Our study illustrates the value of high-resolution HLA and MICA imputation for fine mapping causal variants in the MHC.
Okada, Y. et al. Construction of a population-specific HLA imputation reference panel and its application to Graves' disease risk in Japanese.
We propose a method called CUTOFF imputation that utilizes the spatio-temporal nature of the data to accurately and efficiently impute missing values.
Variants included in the analysis were autosomal SNPs present in HRC imputation file, with a χ2 P value for the Hardy−Weinberg equilibrium >10−10 (calculated using plink and unrelated white British individuals), a call rate >0.95 in unrelated white British individuals, a UKBB imputation score > 0.9 and an MAF >10−4.
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