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Here we used two specific ligands to illustrate calcium dependent internalization into HeLa cells through surface nucleolin: the nucleolin antagonist HB-19 pseudopeptide that binds the RGG domain, and the nucleolin specific monoclonal antibody D3 that binds the second RNA binding domain RBD2 [9], [9] (A.G.H. unpublished data).
Biochemical studies with WHIM-CXCR4 mutants detected impaired ligand-mediated internalization and calcium ion mobilization in some studies [22], [29], but not others [30].
CXCL4 did neither interfere with ligand binding to CXCR3 nor with ligand-induced internalization or calcium signaling of CXCR3.
In addition to characterization of Syk, Lyn, and FcεRI ITAM phosphorylation, receptor internalization, and calcium mobilization, we focused on phosphatases implicated in FcεRI signal regulation.
Whereas the putative sialidase activity of the secreted Klotho may inhibit the internalization of calcium TRPV5 [ 13] and potassium ROMK1 [ 14] channels, the mechanism by which the secreted Klotho isoform inhibits Ins/Igf-like receptor activity remains to be determined.
A chronic effect of maternal antibodies on the fetal heart has been proposed to be mediated by binding of antibodies to calcium channels and subsequent internalization and degradation, leading to not only inefficient signal conduction but also insufficient excitation-contraction coupling and reduction of cardiac contractile function [ 56].
In summary, we provide strong evidence in this study using genetic, pharmacological, enzymatic and immunological interventions that the ganglioside 9-OacGD3 reduces neuroblast migration by decreasing P2Y1R-mediated spontaneous calcium oscillations, due to receptor internalization.
Calcium bisulphate.
Calcium builds up.
Calcium Sulfate.
Calcium aluminate.
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