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As protein expression of TS is not always predictive for the real enzymatic activity in the cells, we then evaluated TS activity by the TS in situ assay, in which intact cells are used, and the drugs are still present in the cells, resulting in an actual measurement of real intracellular TS inhibition.
Since protein expression of TS is not necessarily predictive of the cellular catalytic activity of TS, we hence evaluated TS activity by the TS in situ assay, in which intact H28 and H2452 cells were used.
As in TS, these D1CT-7 ("transgenicansgenic mice׳s tics were alleviated by the TS drugs clonidine and dopamine D2 receptor antagonists; and their chronic glutamate-excited striatal motor output was unbalanced toward hyperactivity of the motoric direct pathway and inactivity of the cataleptic indirect pathway.
In the present study, the ingestion ratio of TS pellets by the O. marmorata juveniles was clearly affected by the TS pellet's pH level.
Here, to provide a higher order view of the transcriptional changes caused by the TS mutation in CACNA1C, we constructed genome-wide transcriptome networks in control and TS neural progenitors and differentiated neurons at rest and following depolarization.
The fault detection test is based on checking the consistency between the measurements and the output estimations provided by the TS observers.
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We also used a permutation test to further validate the results obtained by the t-tests.
p-values were calculated by the t-Student algoritm (one-tail, unpaired).
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