Sentence examples for By elucidation from inspiring English sources

While rational design of these drugs would be aided by elucidation of the sGC three-dimensional structure and molecular mechanism of activation, such efforts also require quantities of high quality enzyme that are challenging to produce.

Our understanding of the assembly and function of U1 snRNP has been greatly enhanced initially by cryo electron microscopy studies [16] and more recently by elucidation of its three-dimensional structure by X-ray crystallography [17].

This finding was later confirmed by elucidation of the three-dimensional X-ray structure of the variant protein.

The cross-talk of RTKs was demonstrated by Western blotting and confirmed by small interfering RNA (siRNA) silencing, followed by elucidation of the underlying mechanism.

These issues potentially could be relieved by elucidation of the relevant biosynthesis – e.g., to enable metabolic engineering to provide access to the targeted natural product or variants thereof either in the native host or recombinant systems.

The Conserved network also provides further evidence that calcineurin activity is highly regulated under physiological conditions by elucidation of the Rcn2 gene, which is known to inhibit calcineurin signaling [ 55].

The model can be improved by experimental elucidation of these regulatory functions and by experimental testing of the model's predictions.

Here, we expand our understanding of chemodenitrification by experimental elucidation of how organic ligands promote abiotic Fe(II) oxidation by nitrite, and discuss its relevance to assessing the potential co-occurrence of chemical and biological Fe(II) oxidation.

If the main motivation for transcriptome sequencing is usually the quantification of gene expression, the transcribed sequences generated by deep sequencing can also contribute to prokaryotic genome annotation by the elucidation of gene structural features, including transcription start sites (TSSs), 5′ and 3′ untranslated regions (UTRs) and the identification of non-coding RNA (ncRNA) genes.

The ligand binding motif unraveled by 1,8-ANS may open new possibilities to treat TTR amyloid diseases by the elucidation of novel candidates for a more specific pharmacophoric pattern.

Brandt would have been dismayed by such elucidation, but how could he object?