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The rates of aortic valve events, ischemic cardiovascular events, cardiovascular death, and combined death from any cause and hospitalization for heart failure because of progression of AS all increased progressively with increasing quartile of baseline LV mass index and were 1.5, 1.8, 3.2, and 2.5 times higher in the upper LV mass index quartile than in the lowest quartile.
Late occlusion is generally related to the end point of graft rejection because of progression of the alloimmune response [8].
Eight of the 11 patients died, one each because of progression of SSc, multiorgan failure, gastrointestinal and pulmonary bleeding, pericardial tamponade and pulmonary complications, diffuse alveolar hemorrhage, pulmonary embolism, graft-versus-host disease, and malignancy.
A total of 31 patients (79%) experienced treatment failure; 22 (56%) who failed therapy had a change in immunosuppressive regimen because of progression (n = 18) or toxicity (n = 4).
Nineteen knees (14%) were revised during the study period because of progression of disease (nine knees), loosening (eight), or pain (two); the mean time to revision was 10.2 years.
The remaining three patients discontinued the drug because of progression of the underlying cancer.
Similar(29)
Compared with RANO, the use of Macdonald criteria might yield a longer PFS because of later identification of progression.
Moreover, about 20% of all patients were taken off study because of clinical progression not according to the protocol, for example, not meeting the criteria of PSA progression.
Treatment was discontinued because of disease progression in six patients, and two patients died within 30 days of their last therapy due to disease progression.
The book ends with Jamie seemingly defeated, unable to bear visiting me because of the progression of my disease.
The remaining 24 patients discontinued because of disease progression assessed by imaging or significant clinical deterioration as assessed by the investigator (Figure 2).
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