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The sensor based on this engineered enzyme showed the highest sensitivity and lowest detection limit in the range of l-lactate concentration 0 1 mM as well as long term stability over one month.
We then developed a reporter assay based on this engineered cell line.
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Based on this, engineers in my company and others, many belonging to institutions such as the IEEE Institute of Electrical and Electronics Engineerss), have got together to develop a standardised technology that will work well with the spectrum identified - "white space spectrum" - and be optimal for machines.
Based on this, we engineered a panel of fidelity variant coxsackievirus B3 polymerases that caused reduced infectivity and attenuated virus growth in mice (Gnädig et al., PNAS, 2012).
The public already knows the United States tortured detainees using interrogation techniques based on those engineered by Communist China and used during the Korean War to coerce confessions, most of them false, from American prisoners.
Based on the engineered alleles, induced animals are referred to as 'TRP' mice.
The TRP model described here can be placed into the classical or mesenchymal subtypes based on the engineered perturbations of RB, PTEN and KRAS, the latter resulting in an activated MAPK pathway.
Based on this mechanism, we engineered a receptor/ligand system to overcome the brain barriers by combining the human transferrin receptor with the cohesin domain from Clostridium thermocellum, and we tested the hybrid receptor in the choroid plexus of the mouse brain with a dockerin ligand.
Based on this observation, we engineered a point mutation (G283P) at the hinge region, in order to stabilize YscD in a less flexible conformation.
For example the Kilgard study on the role of vagus nerve stimulation paired with tones for treating tinnitus was based on this paradigm (Engineer et al., 2011, Nature), and is currently under clinical trial.
Launched at FILTECH in October, this filtration media is based on an engineered gradient structure combining multiple advanced media technologies.
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Justyna Jupowicz-Kozak
CEO of Professional Science Editing for Scientists @ prosciediting.com