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Based on our current knowledge, gene knockout is an effective strategy in genetic engineering for developing high target-compound producing strains.
Based on our current knowledge about DNA methylation, it is reasonable to deduce that DNA methyltransferases may be involved in the DNA methylation recovery process.
Based on our current knowledge of how apoptosis is regulated, we describe here a new model for receptor induced cell death.
Based on our current knowledge of nervous system function, such novel design seems a logical step to be followed by future artificial intelligence.
Based on our current knowledge, we propose a model for protein binding and lipid reorganization as depicted in Figure 9. First, STxB binds via the high affinity binding sites I and II to Gb3 and forms protein clusters.
Based on our current knowledge of FD and what is known so far about IKAP, we presume that the key for effective therapy of FD is increasing the amount of the normal, functional IKAP protein.
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A further limitation of the candidate gene approach is its reliance on the generation of an a-priori hypothesis based on our current incomplete knowledge of the pathophysiology of the disorder.
Comments regarding appropriate use of this treatment are based on our current level of knowledge.
Here, we discuss a few possibilities base on our current knowledge.
Based on the current knowledge and our own experience regarding different imaging modalities, we herewith suggest a pathway for follow-up in patients with KD into adulthood (Fig. 3).
The aim of this paper was to analyse the existing guidelines regarding the cardiovascular follow-up of patients after KD and to propose a new pathway for follow-up, based on the current knowledge and our own experience.
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