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Based on its effectiveness and pharmacokinetic profile, flecainide is used to test the study hypothesis.
Based on its effectiveness in the management of advanced colorectal cancer (Saunders and Iveson, 2006), we hypothesize that the use of oxaliplatin and 5-FU combination may be beneficial in such cases.
The change was made based on its effectiveness in lowering blood glucose, its relatively mild side effect profile (no hypoglycemia or weight gain) and its demonstrated benefit in overweight patients [ 11].
The primary aim was to develop the scoring tool further so that it assigned appropriate scores to each subaction based on its effectiveness for achieving evidence-informed policymaking.
After a series of dedicated experiments, the best hydrotreating catalyst was selected based on its effectiveness in maximizing diesel yield (desired product) while maintaining its quality.
Although a large proportion of patients started on pyrazinamide as part of the ETR were later taken off this drug, its inclusion in the ETR is justified based on its effectiveness among those who might be susceptible.
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There is a marked paucity of high-quality evidence linking rasburicase to improvements in "hard outcomes" such as need for RRT and mortality, and its use is largely based on its dramatic effectiveness in lowering PUA levels, which has been widely used in trials as a surrogate for CTLS and AKI.
In a fourth option, manufacturers price a drug based on its cost-effectiveness, considering the size and characteristics of the patient population with the condition, the potential efficacy of the therapy, and how much money the new drug saves the health system.
Recently, however, TC (paclitaxel and carboplatin) has been begun to be widely applied for treatment of endometrial carcinoma, based on its initial reported effectiveness and high tolerability [ 11– 13].
The most difficult principles to support were "assessing treatment effectiveness based mainly on clinical research," "assessing effectiveness based on its magnitude," and "assessing treatment effectiveness in a patient group, rather than in individual patients".
For patients able to walk on a treadmill without significant baseline ST-segment abnormality, exercise treadmill testing remains the first-line diagnostic test based on its high cost-effectiveness and widespread availability.
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Justyna Jupowicz-Kozak
CEO of Professional Science Editing for Scientists @ prosciediting.com